Biodegradation and tissue reaction to intravitreous biodegradable poly(D,L-lactic-co-glycolic)acid microspheres.

@article{Giordano1995BiodegradationAT,
  title={Biodegradation and tissue reaction to intravitreous biodegradable poly(D,L-lactic-co-glycolic)acid microspheres.},
  author={Giacomo Giordano and Patricia Ch{\'e}vez-Barrios and Miguel F Refojo and Charles A. Garcia},
  journal={Current eye research},
  year={1995},
  volume={14 9},
  pages={761-8}
}
We studied the biodegradation of and the tissue reaction to microspheres of 50:50 poly(D,L-lactic-co-glycolic)acid (PLGA) (viscosity-average MW: 3000 d), injected intravitreous in rabbits. These microspheres are under investigation as injectable devices for intravitreous sustained drug delivery. The rate of intravitreous degradation of PLGA microspheres has not been well documented in the literature. Twenty two pigmented rabbits underwent gas vitrectomy in one eye: 19 eyes received 2.5 mg of… CONTINUE READING