Biodegradation and in vivo biocompatibility of a degradable, polar/hydrophobic/ionic polyurethane for tissue engineering applications.

@article{Mcbane2011BiodegradationAI,
  title={Biodegradation and in vivo biocompatibility of a degradable, polar/hydrophobic/ionic polyurethane for tissue engineering applications.},
  author={Joanne E. Mcbane and Soroor Sharifpoor and Kuihua Cai and Rosalind S. Labow and J Paul Santerre},
  journal={Biomaterials},
  year={2011},
  volume={32 26},
  pages={
          6034-44
        }
}
A degradable, polar/hydrophobic/ionic polyurethane (D-PHI) scaffold was optimized in in vitro studies to yield mechanical properties appropriate to replicate vascular graft tissue while eliciting a more wound-healing phenotype macrophage when compared to established materials. The objectives of this study were to characterize the biodegradation (in vitro and in vivo) and assess the in vivo biocompatibility of D-PHI, comparing it to a well-established, commercially-available scaffold biomaterial… CONTINUE READING

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