Biodegradable star HPMA polymer-drug conjugates: Biodegradability, distribution and anti-tumor efficacy.

@article{Etrych2011BiodegradableSH,
  title={Biodegradable star HPMA polymer-drug conjugates: Biodegradability, distribution and anti-tumor efficacy.},
  author={Tom{\'a}{\vs} Etrych and Lubom{\'i}r Kov{\'a}ř and Jiř{\'i} Strohalm and Petr Chytil and Blanka Ř{\'i}hov{\'a} and Karel Ulbrich},
  journal={Journal of controlled release : official journal of the Controlled Release Society},
  year={2011},
  volume={154 3},
  pages={241-8}
}
Herein, new biodegradable star polymer-doxorubicin conjugates designed for passive tumor targeting were investigated, and their synthesis, physico-chemical characterization, drug release, biodegradation, biodistribution and in vivo anti-tumor efficacy are described. In the conjugates, the core formed by poly(amidoamine) (PAMAM) dendrimers was grafted with semitelechelic N-(2-hydroxypropyl)methacrylamide (HPMA) copolymers bearing doxorubicin (Dox) attached by hydrazone bonds, which enabled… CONTINUE READING
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High-molecular-weight polymers containing biodegradable disulfide bonds: synthesis and in vitro verification of intracellular degradation

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