Biodegradable sirolimus-loaded poly(lactide) nanoparticles as drug delivery system for the prevention of in-stent restenosis in coronary stent application.

@article{Luderer2011BiodegradableSP,
  title={Biodegradable sirolimus-loaded poly(lactide) nanoparticles as drug delivery system for the prevention of in-stent restenosis in coronary stent application.},
  author={Frank Luderer and Marian Loebler and Henning W Rohm and Christian Gocke and Katharina Kunna and Kathleen K{\"o}ck and Heyo Klaus Kroemer and Werner Weitschies and Klaus-Peter Schmitz and K. Sternberg},
  journal={Journal of biomaterials applications},
  year={2011},
  volume={25 8},
  pages={851-75}
}
The administration of drugs using biodegradable polymer nanoparticles as carriers has generated immense interest due to their excellent biocompatibility and the prolonged drug release. The scope of this work was to determine the applicability of sirolimus-loaded biodegradable poly(D,L-lactide) (PDLLA) nanoparticles as drug carriers to prevent restenotic processes after stent implantation. The average 250 nm sized 20%(w/w) sirolimus-loaded nanoparticles were extensively characterized with regard… CONTINUE READING
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