Biodegradable scleral implant for intravitreal controlled release of ganciclovir

  title={Biodegradable scleral implant for intravitreal controlled release of ganciclovir},
  author={Tsutomu Yasukawa and Hideya Kimura and Noriyuki Kunou and Hideki Miyamoto and Y. Hasegawa Honda and Yuichiro Ogura and Yoshito Ikada},
  journal={Graefe's Archive for Clinical and Experimental Ophthalmology},
· Background: The aims of this study were to develop biodegradable scleral implants that could overcome previously reported disadvantages such as an adverse burst in the late phase of release and to investigate the release profile of modified scleral implants in vitro and in vivo. · Methods:The modified scleral implants (weight 8.5 mg, length 5 mm) were made of mixtures of poly(dl-lactide) (PLA) with different molecular weights and contained 25 weight % of ganciclovir (GCV). The release of GCV… CONTINUE READING
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