Biodegradable polymeric vectors for gene delivery to human endothelial cells.

@article{Green2006BiodegradablePV,
  title={Biodegradable polymeric vectors for gene delivery to human endothelial cells.},
  author={Jordan J Green and Julie Shi and Eugene Chiu and Elizaveta S. Leshchiner and Robert Langer and Daniel G Anderson},
  journal={Bioconjugate chemistry},
  year={2006},
  volume={17 5},
  pages={
          1162-9
        }
}
Endothelial cells are an important cell type to both cardiovascular disease and cancer, as they play critical roles in vascular function and angiogenesis. However, effective and safe gene delivery to primary endothelial cells in the presence of serum proteins is known to be particularly challenging. A library of biodegradable poly(beta-amino esters) was synthesized for use as potential vectors. Promising vectors were optimized for high efficacy and low cytotoxicity to human umbilical vein… CONTINUE READING

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