Biodegradable polymer nanoparticles that rapidly penetrate the human mucus barrier.

Abstract

Protective mucus coatings typically trap and rapidly remove foreign particles from the eyes, gastrointestinal tract, airways, nasopharynx, and female reproductive tract, thereby strongly limiting opportunities for controlled drug delivery at mucosal surfaces. No synthetic drug delivery system composed of biodegradable polymers has been shown to penetrate… (More)
DOI: 10.1073/pnas.0905998106

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