Biodegradable polymer microneedles: fabrication, mechanics and transdermal drug delivery.

  title={Biodegradable polymer microneedles: fabrication, mechanics and transdermal drug delivery.},
  author={Jung-Hwan Park and Mark G. Allen and Mark R. Prausnitz},
  journal={Journal of controlled release : official journal of the Controlled Release Society},
  volume={104 1},
To overcome the skin's barrier properties that block transdermal delivery of most drugs, arrays of microscopic needles have been microfabricated primarily out of silicon or metal. This study addresses microneedles made of biocompatible and biodegradable polymers, which are expected to improve safety and manufacturability. To make biodegradable polymer microneedles with sharp tips, micro-electromechanical masking and etching were adapted to produce beveled- and chisel-tip microneedles and a new… CONTINUE READING
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