Biodegradable poly(amine-co-ester) terpolymers for targeted gene delivery.

  title={Biodegradable poly(amine-co-ester) terpolymers for targeted gene delivery.},
  author={Jiangbing Zhou and Jie Liu and Christopher J. Cheng and T.R. Patel and Caroline E. Weller and Joseph M. Piepmeier and Zhaozhong Jiang and W. Mark Saltzman},
  journal={Nature materials},
  volume={11 1},
Many synthetic polycationic vectors for non-viral gene delivery show high efficiency in vitro, but their usually excessive charge density makes them toxic for in vivo applications. Here we describe the synthesis of a series of high molecular weight terpolymers with low charge density, and show that they exhibit efficient gene delivery, some surpassing the efficiency of the commercial transfection reagents Polyethylenimine and Lipofectamine 2000. The terpolymers were synthesized via enzyme… 

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  • M. PiestJ. Engbersen
  • Biology
    Journal of controlled release : official journal of the Controlled Release Society
  • 2010

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