Biodegradable poly(ethylene glycol) hydrogels based on a self-elimination degradation mechanism.

Abstract

Two vinyl sulfone functionalized crosslinkers were developed for the purpose of preparing degradable poly(ethylene glycol) (PEG) hydrogels (EMXL and GABA-EMXL hydrogels). A self-elimination degradation mechanism in which an N-terminal residue of a glutamine is converted to pyroglutamic acid with subsequent release of diamino PEG (DAP) is proposed. The… (More)
DOI: 10.1016/j.biomaterials.2010.05.021

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