Biodegradable nanoparticles for controlled subconjunctival delivery of latanoprost acid: in vitro and in vivo evaluation. Preliminary results.

@article{Giarmoukakis2013BiodegradableNF,
  title={Biodegradable nanoparticles for controlled subconjunctival delivery of latanoprost acid: in vitro and in vivo evaluation. Preliminary results.},
  author={Athanassios Giarmoukakis and Georgios Labiris and Haris Sideroudi and Zinovia Tsimali and Nefeli Koutsospyrou and Konstantinos Avgoustakis and Vassilios Kozobolis},
  journal={Experimental eye research},
  year={2013},
  volume={112},
  pages={
          29-36
        }
}
Purpose of the study was to develop and assess a novel controlled drug delivery system of latanoprost acid (LA). Poly(lactide)/Monomethoxy-poly(ethyleneglycol) (PLA-PEG) nanoparticles (NPs) were prepared using an emulsification-solvent evaporation technique. NPs were characterized in vitro according to their size, ζ-potential, drug entrapment efficiency and LA release. LA-loaded NPs (equivalent to 8.5 μg LA) were administered into the subconjunctival space of normotensive rabbits (group A). A… CONTINUE READING

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