Biodegradable microgrooved polymeric surfaces obtained by photolithography for skeletal muscle cell orientation and myotube development.

@article{Altomare2010BiodegradableMP,
  title={Biodegradable microgrooved polymeric surfaces obtained by photolithography for skeletal muscle cell orientation and myotube development.},
  author={Lina Altomare and Nikolaj Gadegaard and Livia Visai and M. Cristina Tanzi and Silvia Far{\'e}},
  journal={Acta biomaterialia},
  year={2010},
  volume={6 6},
  pages={1948-57}
}
During tissue formation, skeletal muscle precursor cells fuse together to form multinucleated myotubes. To understand this mechanism, in vitro systems promoting cell alignment need to be developed; for this purpose, micrometer-scale features obtained on substrate surfaces by photolithography can be used to control and affect cell behaviour. This work was aimed at investigating how differently microgrooved polymeric surfaces can affect myoblast alignment, fusion and myotube formation in vitro… CONTINUE READING
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