Biodegradable in situ gel-forming controlled drug delivery system based on thermosensitive PCL-PEG-PCL hydrogel: part 1--Synthesis, characterization, and acute toxicity evaluation.

@article{Gong2009BiodegradableIS,
  title={Biodegradable in situ gel-forming controlled drug delivery system based on thermosensitive PCL-PEG-PCL hydrogel: part 1--Synthesis, characterization, and acute toxicity evaluation.},
  author={Changyang Gong and S. K.-Y. Shi and Peng Dong and Bing Yang and Xiao Rong Qi and Gang Guo and Ying Chun Gu and Xia Zhao and Yu Quan Wei and Zhiyong Qian},
  journal={Journal of pharmaceutical sciences},
  year={2009},
  volume={98 12},
  pages={4684-94}
}
In this work, biodegradable PCL-PEG-PCL (PCEC) triblock copolymers were successfully synthesized at one-step. Aqueous solution of PCEC copolymer displayed thermosensitive sol-gel-sol transition behavior, which is flowing sol at low temperature and turns into non-flowing gel at body temperature. The cytotoxicity of PCEC copolymer was evaluated by cell viability assay using HEK293 and WISH cells. In vivo gel-formation, degradation test, acute toxicity tests, and histopathological study of PCEC… CONTINUE READING

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