Biodegradable implants for potential use in bone infection

  title={Biodegradable implants for potential use in bone infection},
  author={B. Mousset and M. A. Benoit and Ch. Delloye and R. Bouillet and Joel Gillard},
  journal={International Orthopaedics},
Local antibiotic therapy by diffusion from plaster of Paris beads has proved promising in bone surgery. Sustained local delivery depends on thermostability, so we tested the antibacterial activity of 11 antibiotic solutions after storage at 37°C using a microbiological method. Cephalosporins and penicillins were unstable, but aminoglycosides remained fully stable with 100% activity after 2 weeks. About 60% of the initial bactericidal activity of quinolone, glycopeptides and sodium fusidate were… CONTINUE READING


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