Biodegradable hyaluronic acid hydrogels to control release of dexamethasone through aqueous Diels-Alder chemistry for adipose tissue engineering.

@article{Fan2015BiodegradableHA,
  title={Biodegradable hyaluronic acid hydrogels to control release of dexamethasone through aqueous Diels-Alder chemistry for adipose tissue engineering.},
  author={Ming Yu Fan and Ye Ma and Ziwei Zhang and Jiahui Mao and Huaping Tan and Xiaohong Hu},
  journal={Materials science & engineering. C, Materials for biological applications},
  year={2015},
  volume={56},
  pages={311-7}
}
A robust synthetic strategy of biopolymer-based hydrogels has been developed where hyaluronic acid derivatives reacted through aqueous Diels-Alder chemistry without the involvement of chemical catalysts, allowing for control and sustain release of dexamethasone. To conjugate the hydrogel, furan and maleimide functionalized hyaluronic acid were synthesized, respectively, as well as furan functionalized dexamethasone, for the covalent immobilization. Chemical structure, gelation time… CONTINUE READING