Biodegradable gelatin microspheres enhance the neuroprotective potency of osteopontin via quick and sustained release in the post-ischemic brain.

@article{Jin2014BiodegradableGM,
  title={Biodegradable gelatin microspheres enhance the neuroprotective potency of osteopontin via quick and sustained release in the post-ischemic brain.},
  author={Yinchuan Jin and In-Yong Kim and Il-Doo Kim and Hye-Kyung Lee and Jin-Young Park and Pyung-Lim Han and Kyekyoon Kevin Kim and Hyungsoo Choi and Ja-Kyeong Lee},
  journal={Acta biomaterialia},
  year={2014},
  volume={10 7},
  pages={
          3126-35
        }
}
Gelatin microspheres (GMSs) are widely used as drug carriers owing to their excellent biocompatibilities and toxicologically safe degradation products. The drug release profile is easily tailored by controlling the cross-linking density and surface-to-volume ratio, i.e. size, of the GMS. In this study, we employed GMSs which are 25 μm in diameter and cross-linked with 0.03125% glutaraldehyde, to enable rapid initial and a subsequent sustained release. Therapeutic potency of human recombinant… CONTINUE READING
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Gelatin nanoparticles enhance the neuroprotective effects of intranasally administered osteopontin in rat ischemic stroke model

  • Drug Delivery and Translational Research
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Current developments in cell- and biomaterial-based approaches for stroke repair.

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