Biodegradable gelatin microparticles as delivery systems for the controlled release of bone morphogenetic protein-2.

@article{Patel2008BiodegradableGM,
  title={Biodegradable gelatin microparticles as delivery systems for the controlled release of bone morphogenetic protein-2.},
  author={Zarana S. Patel and Masaya Yamamoto and Hiroki R Ueda and Yasuhiko Tabata and Antonios G Mikos},
  journal={Acta biomaterialia},
  year={2008},
  volume={4 5},
  pages={1126-38}
}
This work evaluated gelatin microparticles and biodegradable composite scaffolds for the controlled release of bone morphogenetic protein-2 (BMP-2) in vitro and in vivo. Gelatin crosslinking (10 and 40mM glutaraldehyde), BMP-2 dose (6 and 60ng BMP-2 per mg dry microparticles), buffer type (phosphate buffered saline (PBS) and collagenase-containing PBS), and gelatin type (acidic and basic) were investigated for their effects on BMP-2 release. Release profiles were also observed using poly(lactic… CONTINUE READING

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References

Publications referenced by this paper.
Showing 1-10 of 46 references

Controlled delivery of angiogenic and osteogenic growth factors for bone regeneration

ZS Patel
Houston, TX: Rice University; • 2008
View 1 Excerpt

Gelatin as a delivery vehicle for the controlled release of bioactive molecules.

Journal of controlled release : official journal of the Controlled Release Society • 2005
View 1 Excerpt

Transforming growth factor-beta 1 release from oligo(poly(ethylene glycol) fumarate) hydrogels in conditions that model the cartilage wound healing environment

TA Holland, JK Tessmar, Y Tabata, AG. Mikos
J Control Release • 2004
View 1 Excerpt

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