• Corpus ID: 94682044

Biodegradable drug eluting coating of cardiovascular stents dewets and can cause thrombosis

  title={Biodegradable drug eluting coating of cardiovascular stents dewets and can cause thrombosis},
  author={Alexey Kondyurin and Irina Kondyurina and Marcela M. M. Bilek},
  journal={arXiv: Chemical Physics},
The results of our investigation of ion implantation of PLGA show that the PLGA films undergo crosslinking, carbonization and etching. The PLGA coating degrades in water by a hydrolysis reaction. The dewetting of PLGA coating under water is observed on silicon wafer, metal and carbon surfaces. As the result, the coating is ruptured up to separate drops of PLGA on the surface. The dewetting process can be eliminated by an ion beam implantation treatment, when the ions penetrate through the whole… 
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