• Corpus ID: 94682044

Biodegradable drug eluting coating of cardiovascular stents dewets and can cause thrombosis

@article{Kondyurin2011BiodegradableDE,
  title={Biodegradable drug eluting coating of cardiovascular stents dewets and can cause thrombosis},
  author={Alexey Kondyurin and Irina Kondyurina and Marcela M. M. Bilek},
  journal={arXiv: Chemical Physics},
  year={2011}
}
The results of our investigation of ion implantation of PLGA show that the PLGA films undergo crosslinking, carbonization and etching. The PLGA coating degrades in water by a hydrolysis reaction. The dewetting of PLGA coating under water is observed on silicon wafer, metal and carbon surfaces. As the result, the coating is ruptured up to separate drops of PLGA on the surface. The dewetting process can be eliminated by an ion beam implantation treatment, when the ions penetrate through the whole… 
Biodegradable Metals for Cardiovascular Stent Application: Interests and New Opportunities
TLDR
The recent developments in the design and evaluation of metallic materials for biodegradable stents are reviewed and the new metallurgical processes which could be applied for the production of metallic biodegrades and their effect on the properties of the produced metals are introduced.
Ion Beam Modification of Biodegradable Polymeric Biomaterials
TLDR
By products of biodegradable polymers leaves no residual mass at the application site, this makes these polymers biocompatible which is very important for host response.

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