Biodegradable drug delivery system for the treatment of bone infection and repair.

@article{Silvio1999BiodegradableDD,
  title={Biodegradable drug delivery system for the treatment of bone infection and repair.},
  author={Lucy Di Silvio and William Bonfield},
  journal={Journal of materials science. Materials in medicine},
  year={1999},
  volume={10 10/11},
  pages={653-8}
}
A drug delivery system (DDS) which provides a sustained release of antibiotics at the focal site either singly, or in combination with a bone stimulating factor could both eliminate infection and increase the number of potentially healthy osteogenic cells. In this study, we address the use of a degradable gelatin DDS, for the combined release of therapeutic levels of both gentamicin and growth hormone (GH). An initial bolus release was observed during the first 24 h followed by a reduced, but… CONTINUE READING

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