Biodegradable donepezil lipospheres for depot injection: optimization and in-vivo evaluation.

OBJECTIVES The purpose of this study was to develop an injectable depot liposphere delivery system with high loading capacity for controlled delivery of donepezil to decrease dosing frequency and increase patient compliance. METHODS A 3(2) full factorial design was employed to study the effect of lipid type and drug-to-lipid ratio on the yield… CONTINUE READING