Biodegradable cationic polyester as an efficient carrier for gene delivery to neonatal cardiomyocytes.

  title={Biodegradable cationic polyester as an efficient carrier for gene delivery to neonatal cardiomyocytes.},
  author={Peisheng Xu and Shi-Yan Li and Qiang Li and Jun Ren and Edward Alva Van Kirk and W. James Murdoch and M. Radosz and Youqing Shen},
  journal={Biotechnology and bioengineering},
  volume={95 5},
Viral-mediated gene delivery has been explored for the treatment and protection of cardiomyocytes, but so far there is only one report using cationic polymer for gene delivery to cardiomyocytes in spite of many advantages of polymer-mediated gene delivery. In this study, a cationic poly(beta-amino ester) (PDMA) with a degradable backbone and cleavable side chains was synthesized by Michael addition reaction. The toxicity of PDMA to neonatal mouse cardiomyocytes (NMCMs) was significantly lower… CONTINUE READING
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