Biodegradable block copolymers for delivery of proteins and water-insoluble drugs.

@article{Zentner2001BiodegradableBC,
  title={Biodegradable block copolymers for delivery of proteins and water-insoluble drugs.},
  author={Gaylen M. Zentner and Ramesh Rathi and Chun-Che Shih and Jane McRea and Min Hyo Seo and Hunseung Oh and Byung Geon Rhee and Jiri F. Mestecky and Zina Moldoveanu and Mary S. Morgan and Steve Weitman},
  journal={Journal of controlled release : official journal of the Controlled Release Society},
  year={2001},
  volume={72 1-3},
  pages={203-15}
}
Release of several drugs from new ABA-type biodegradable thermal gels, ReGel, including proteins and conventional molecules, are presented. These are biodegradable, biocompatible polymers that demonstrate reverse thermal gelation properties. Organic solvents are not used in the synthesis, purification, or formulation of these polymers. The unique characteristics of ReGel hinge on the following two key properties: (1) ReGel is a water soluble, biodegradable polymer at temperatures below the gel… CONTINUE READING