Biodegradable and injectable in situ cross-linking chitosan-hyaluronic acid based hydrogels for postoperative adhesion prevention.

@article{Li2014BiodegradableAI,
  title={Biodegradable and injectable in situ cross-linking chitosan-hyaluronic acid based hydrogels for postoperative adhesion prevention.},
  author={Ling Li and Ning Wang and Xun Jin and Rui Deng and Shihong Nie and Lu Sun and Qin Jie Wu and Yu-quan Wei and Changyang Gong},
  journal={Biomaterials},
  year={2014},
  volume={35 12},
  pages={
          3903-17
        }
}
Postsurgical peritoneal adhesions are very common and serious complication after surgery. Biodegradable and injectable hydrogels derived from natural polysaccharides are ideal biomaterials for prevention of postoperative adhesion. In this work, we report a class of injectable, biodegradable, and non-toxic hydrogel derived from N, O-carboxymethyl chitosan (NOCC) and aldehyde hyaluronic acid (A-HA), without requirement of any chemical linkers or radiant light sources. NOCC was prepared by… CONTINUE READING
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