Biodegradable Pseudolatexes: The Chemical Stability of Poly(D,L-Lactide) and Poly (ε-Caprolactone) Nanoparticles in Aqueous Media

@article{Coffin2004BiodegradablePT,
  title={Biodegradable Pseudolatexes: The Chemical Stability of Poly(D,L-Lactide) and Poly (ε-Caprolactone) Nanoparticles in Aqueous Media},
  author={Mark D. Coffin and James W. McGinity},
  journal={Pharmaceutical Research},
  year={2004},
  volume={9},
  pages={200-205}
}
Pseudolatexes of the biodegradable polyesters poly(D,L-lactide) (PLA) and poly(ε-caprolactone) (PCL) have been developed as potential aqueous coatings for sustained release. Since PLA and PCL are known to hydrolyze, the influence of the surfactant system, temperature, pH, and particle size on the chemical stability of the polymers as aqueous colloidal dispersions was investigated. Pseudolatexes of PLA and PCL formulated with a nonionic surfactant system were the most stable. When these… CONTINUE READING

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