Biodegradable PAMAM ester for enhanced transfection efficiency with low cytotoxicity.

@article{Nam2009BiodegradablePE,
  title={Biodegradable PAMAM ester for enhanced transfection efficiency with low cytotoxicity.},
  author={Hye Yeong Nam and Kihoon Nam and Hwa Jeong Hahn and Bo Hye Kim and Hyun Jung Lim and Hyun Jin Kim and Joon Sig Choi and Jong-sang Park},
  journal={Biomaterials},
  year={2009},
  volume={30 4},
  pages={
          665-73
        }
}
We synthesized biodegradable polycationic PAMAM (polyamidoamine) esters (e-PAM-R, e-PAM-K) that contain arginines or lysines at the peripheral ends of PAMAM-OH dendrimer through ester bond linkages. The PAMAM esters were readily degradable under physiological conditions (pH 7.4, 37 degrees C), with more than 50% of the grafted amino acids hydrolyzed within 5h. However, polyplexes were very stable and were hardly degraded in the endosomal pH range. Moreover, these amino-acid-modified polymers… CONTINUE READING
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