Biodegradable Nanoparticles Improve Oral Bioavailability of Amphotericin B and Show Reduced Nephrotoxicity Compared to Intravenous Fungizone®

@article{Italia2009BiodegradableNI,
  title={Biodegradable Nanoparticles Improve Oral Bioavailability of Amphotericin B and Show Reduced Nephrotoxicity Compared to Intravenous Fungizone{\textregistered}},
  author={J. L. Italia and Muwafaq Mohammed Yahya and D. Singh and Majeti N. V. Ravi Kumar},
  journal={Pharmaceutical Research},
  year={2009},
  volume={26},
  pages={1324-1331}
}
PurposeAmphotericin B (AMB), an effective antifungal and antileishmanial agent associated with low oral bioavailability (0.3%) and severe nephrotoxicity, was entrapped into poly(lactide-co-glycolide) (PLGA) nanoparticles to improve the oral bioavailability and to minimize the adverse effects associated with it.Materials and MethodsThe AMB-nanoparticles (AMB-NP) were prepared by nanoprecipitation method employing Vitamin E-TPGS as a stabilizer. In vitro release was carried out using membrane… 
Stealth Amphotericin B nanoparticles for oral drug delivery: In vitro optimization
TLDR
There was a significant reduction in MPS, drug content and drug release, when AmB NPs were prepared using the diblock polymer PLGA–PEG with 15% PEG, and this developed formulations are feasible, effective and improved alternatives to other carriers for oral delivery of AmB.
Oral administration of amphotericin B nanoparticles: antifungal activity, bioavailability and toxicity in rats
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The novel AMB formulations showed minimal toxicity and better efficacy compared to Fungizone® in rats, and an oral delivery system of AMB-loaded to PLGA-PEG NPs with better efficacy and minimal toxicity was formulated.
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Results confirm that NANO-D-AMB improves Amphotericin B delivery and suggest this delivery system as a potential alternative to the use of Amphoteric in B sodium deoxycholate.
Design, development and evaluation of mannosylated oral Amphotericin B nanoparticles for anti-leishmanial therapy: Oral kinetics and macrophage uptake studies
Abstract Background The aim of the present research was to develop Mannosylated Amphotericin B nanoparticles (AmB-BSA-MAN NPs) for targeting M-cells in Peyers patch to enhance drug transport across
Efficient antileishmanial activity of amphotericin B and piperine entrapped in enteric coated guar gum nanoparticles
TLDR
In vivo evaluation of a nanoformulation of AmB and piperine (Pip) for therapeutic efficacy in golden hamster- L. donovani model demonstrated enhanced drug bioavailability, non-nephrotoxic nature, and potential antileishmanial activity with up to 96% inhibition of the parasite.
Peroral Amphotericin B Polymer Nanoparticles Lead to Comparable or Superior In Vivo Antifungal Activity to That of Intravenous Ambisome® or Fungizone™
TLDR
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Lyotropic Liquid Crystalline Nanoparticles of Amphotericin B: Implication of Phytantriol and Glyceryl Monooleate on Bioavailability Enhancement
TLDR
It can be concluded that acid-resistant lipid, PT, can be utilized efficiently as an alternate lipid for the preparation of LCNPs to enhance bioavailability and to reduce nephrotoxicity of the drug as compared to other frequently used lipid, i.e., GMO.
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