Biodegradable Nanoparticles Containing Doxorubicin-PLGA Conjugate for Sustained Release

Abstract

Purpose. Doxorubicin was chemically conjugated to a terminal end group of poly(D,L-lactic-co-glycolic acid) [PLGA] and the doxorubicin-PLGA conjugate was formulated into nanoparticles to sustain the release of doxorubicin. Methods. A hydroxyl terminal group of PLGA was activated by p-nitrophenyl chloroformate and reacted with a primary amine group of… (More)
DOI: 10.1023/A:1018908421434

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