Biodegradable, Elastic Shape-Memory Polymers for Potential Biomedical Applications

  title={Biodegradable, Elastic Shape-Memory Polymers for Potential Biomedical Applications},
  author={Andreas Lendlein and Robert S. Langer},
  pages={1673 - 1676}
The introduction of biodegradable implant materials as well as minimally invasive surgical procedures in medicine has substantially improved health care within the past few decades. This report describes a group of degradable thermoplastic polymers that are able to change their shape after an increase in temperature. Their shape-memory capability enables bulky implants to be placed in the body through small incisions or to perform complex mechanical deformations automatically. A smart… 
Shape memory polymers and their composites in biomedical applications.
Biodegradable Shape Memory Polymers in Medicine
This review provides an overview of biodegradable shape memory polymers that have been used in medical applications and their potential to facilitate the optimization and development of new medical applications.
Biomedical applications of thermally activated shape memory polymers.
The various biomedical applications of SMPs and the challenges they face with respect to actuation and biocompatibility are reviewed.
Shape-Memory Polymers for Biomedical Applications
This review focuses on several areas of biomedicine including vascular, orthopedic, and neuronal applications with respect to the progress and potential for SMPs to improve the standard of treatment in these areas.
Biodegradable Shape-Memory Polymers
In this chapter, the main characteristics of these materials and their applications in biomedicine are described.
Recent Advances in Shape Memory Soft Materials for Biomedical Applications.
This review discusses the design considerations critical to the successful integration of SMPs for use in vivo, and highlights recent work on three classes of S MPs: shape memory polymers and blends, shape memory polymer composites, and shape memory hydrogels.
Shape-memory polymers as a technology platform for biomedical applications
Shape-memory polymers, as described herein regarding their general principle, compositions and architectures, have developed to a technology platform that allows the tailored design of such multifunctionality and enables the development of novel medical devices that will be clinically evaluated in the near future.
Controlled Drug Release from Biodegradable Shape-Memory Polymers
Drug loading and release, drug effects on thermomechanical properties of SMPs, and drug release patterns in a physiological environment are described and potential applications in minimally-invasive surgery are discussed.


Polymere als Implantatwerkstoffe
Polymers are already being used as implant materials in several biomedical applications by today. The present paper shows actual concepts for innovative degradable biomaterials as well as established
AB-polymer networks based on oligo(epsilon-caprolactone) segments showing shape-memory properties.
A polymer system of shape-memory polymer networks based on oligo(epsilon-caprolactone) dimethacrylate as crosslinker and n-butyl acrylateas comonomer was introduced, and key parameters for the programming procedure of the temporary shape have been evaluated.
Shape memory behaviour in partially stabilized zirconia ceramics
Shape memory behaviour has been observed in a variety of metallic alloys. It is usually associated with specific materials which on being deformed to various degrees of inelastic strain, return to
Shape memory behaviors of crosslinked copolymers containing stearyl acrylate
Shape memory polymers were prepared by copolymerizing stearyl acrylate and methyl acrylate. The principle of this shape memory effect is based on reversible order-disorder transition of the
Study on shape‐memory behavior of polyether‐based polyurethanes. I. Influence of the hard‐segment content
Shape-memory polyurethanes (PUs) were synthesized by 4,4′-diphenylmethane diisocyanate (MDI), 1,4-butanediol (BD), and poly(tetramethyl oxide)glycol (PTMO). The morphology of PUs was studied using
Study on shape‐memory behavior of polyether‐based polyurethanes. II. Influence of soft‐segment molecular weight
Polyurethanes (PUs) of a suitable molar ratio of monomers were found to have shape-memory behavior. In this study, four series of PUs were synthesized by 4,4′-diphenylmethane diisocyanate (MDI),
Synthesis and Application of Modulated Polymer Gels
A class of environmentally responsive materials based on the spatial modulation of the chemical nature of gels is proposed and demonstrated here and has an internally heterogeneous or modulated structure.
Structure and properties of shape-memory polyurethane block copolymers
Segmented polyurethanes containing soft segments with lower molecular weight exhibit shape-memorizing properties. Structure and properties of shape-memorizing polyurethanes (S-PUs) were studied.
The chick chorioallantoic membrane as test system for biocompatible materials
  • K. Spanel‐Borowski
  • Medicine, Biology
    Research in experimental medicine. Zeitschrift fur die gesamte experimentelle Medizin einschliesslich experimenteller Chirurgie
  • 1989
The correlation allows consideration of the chick chorioallantoic membrane as an in vivo model in screening materials for their biocompatibility and their connective tissue reaction.