Bioconversion of milbemycin-related compounds: biosynthetic pathway of milbemycins.

  title={Bioconversion of milbemycin-related compounds: biosynthetic pathway of milbemycins.},
  author={Kiyoko Nonaka and C Kumasaka and Yasuko Okamoto and Fumito Maruyama and Hiromichi Yoshikawa},
  journal={The Journal of antibiotics},
  volume={52 2},
Streptomyces hygroscopicus subsp. aureolacrimosus SANK 60286 and SANK 60576 produce many kinds of milbemycins. Among them, milbemycin alpha11, alpha14, A3, and A4 have the most effective acaricidal activity. In this study, we investigated the terminal biosynthetic pathway to milbemycin alpha14 and A4 which accumulated as the final products in these strains. Using cerulenin, a specific inhibitor of fatty acid and polyketide biosynthesis, we conducted bioconversion experiments with cultures of… CONTINUE READING

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