Biocontrolled formal inversion or retention of L-α-amino acids to enantiopure (R)- or (S)-hydroxyacids.

Abstract

Natural L-α-amino acids and L-norleucine were transformed to the corresponding α-hydroxy acids by formal biocatalytic inversion or retention of absolute configuration. The one-pot transformation was achieved by a concurrent oxidation reduction cascade in aqueous media. A representative panel of enantiopure (R)- and (S)-2-hydroxy acids possessing aliphatic, aromatic and heteroaromatic moieties were isolated in high yield (67-85 %) and enantiopure form (>99 % ee) without requiring chromatographic purification.

DOI: 10.1002/chem.201403195

Cite this paper

@article{Busto2014BiocontrolledFI, title={Biocontrolled formal inversion or retention of L-α-amino acids to enantiopure (R)- or (S)-hydroxyacids.}, author={E . Nebot del Busto and Nina Richter and Barbara Grischek and Wolfgang Kroutil}, journal={Chemistry}, year={2014}, volume={20 35}, pages={11225-8} }