Biocontainment strategies for live lactic acid bacteria vaccine vectors.

@article{Lee2010BiocontainmentSF,
  title={Biocontainment strategies for live lactic acid bacteria vaccine vectors.},
  author={Peter Lee},
  journal={Bioengineered bugs},
  year={2010},
  volume={1 1},
  pages={75-7}
}
Stability is an important issue when engineering bacteria for use as live vaccine vectors. For the majority of live bacterial vaccines, the antigen-encoding gene is either plasmid located or integrated into the chromosome. Regardless, several safety concerns can be raised for both instances. One concern when using plasmid-encoded antigens is the transfer of… CONTINUE READING