Biocompatible near-infrared quantum dots delivered to the skin by microneedle patches record vaccination

  title={Biocompatible near-infrared quantum dots delivered to the skin by microneedle patches record vaccination},
  author={Kevin J. McHugh and Lihong Jing and Sean Y. Severt and Mache Cruz and Morteza Sarmadi and H Surangi N Jayawardena and Collin F. Perkinson and Fridrik Larusson and Sviatlana Rose and Stephanie Tomasic and Tyler Graf and Stephany Y. Tzeng and James L. Sugarman and Daniel Vlasic and Matthew Peters and Nels Peterson and Lowell Wood and Wen Tang and Jihyeon Yeom and Joe Collins and Philip A. Welkhoff and Ari Karchin and Megan W Tse and Mingyuan Gao and Moungi G. Bawendi and Robert S. Langer and Ana Jaklenec},
  journal={Science Translational Medicine},
Near-infrared fluorescent microparticles administered to the skin via dissolvable microneedle patches can record vaccine delivery. On the record Vaccines prevent disease and save lives; however, lack of standardized immunization recordkeeping makes it challenging to track vaccine coverage across the world. McHugh et al. developed dissolvable microneedles that deliver patterns of near-infrared light-emitting microparticles to the skin. Particle patterns are invisible to the eye but can be imaged… 

Trends in Drug- and Vaccine-based Dissolvable Microneedle Materials and Methods of Fabrication.

  • Lyndsey E. MooreS. VucenA. Moore
  • Biology
    European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V
  • 2022

Transmitting Light Through Biocompatible and Biodegradable Drug Delivery Micro Needles

It is shown that it is possible to fabricate microneedles able to focus and transmit light, and how an electro-drawnmicroneedle can be used as a sort of light guiding micro-photonic element at the aim to delivery light form its tip.

Smart Mushroom-Inspired Imprintable and Lightly Detachable (MILD) Microneedle Patterns for Effective COVID-19 Vaccination and Decentralized Information Storage

A smart mushroom-inspired imprintable and lightly detachable (MILD) microneedle platform for the effective and convenient delivery of multidose COVID-19 vaccines and decentralized vaccine information storage and serves as a promising carrier to improve CO VID-19 vaccination efficacy through its dual capabilities of vaccine delivery and in situ data storage.

A two-dimensional MXene potentiates a therapeutic microneedle patch for photonic implantable medicine in the second NIR biowindow.

A soluble polyvinylpyrrolidone (PVP) microneedle system loaded with a two-dimensional MXene (Nb2C nanosheets) for medical implantation and photothermal ablation of superficial tumors in the second near infrared biological window (NIR-II).

Biocompatible Light Guide‐Assisted Wearable Devices for Enhanced UV Light Delivery in Deep Skin

A skin‐integrated optoelectronic device that incorporates an array of UVA (360 nm) light emitting diodes in layouts that match those of typical lesional plaques and in designs that couple to biocompatible, penetrating polymer microneedle light waveguides to provide optical access to deep skin is introduced.

Microneedle patch for the ultrasensitive quantification of protein biomarkers in interstitial fluid

The use of a microneedle patch for fast in vivo sampling and on-needle quantification of target protein biomarkers in interstitial fluid allows for longitudinal monitoring of the levels of a range of disease-relevant biomarkers, as shown in live mice.

Transdermal Composite Microneedle Composed of Mesoporous Iron Oxide Nanoraspberry and PVA for Androgenetic Alopecia Treatment

A magneto-responsive transdermal composite microneedle (MNs) with a mesoporous iron oxide nanoraspberry (MIO), that can improve the drug delivery efficiency, was fabricated by using a 3D printing-molding method.

Engineered Microneedles for Interstitial Fluid Cell‐Free DNA Capture and Sensing Using Iontophoretic Dual‐Extraction Wearable Patch

An engineered wearable epidermal system is presented with a combination of reverse iontophoresis and MNs for rapid capture and sensing of Epstein‐Barr virus cell‐ free DNA (an important biomarker of nasopharyngeal carcinoma) and opens an innovative route for minimally invasive sampling of ISF for cell‐free DNA‐related cancer screening and prognosis.

Microneedles for painless transdermal immunotherapeutic applications.




Cross-Linked Fluorescent Supramolecular Nanoparticles as Finite Tattoo Pigments with Controllable Intradermal Retention Times.

Cross-linked fluorescent supramolecular nanoparticles (c-FSNPs) are introduced as a "finite tattoo" pigment, with optimized photophysical properties and intradermal retention time to achieve successful in vivo finite tattooing.

Improved immunogenicity of individual influenza vaccine components delivered with a novel dissolving microneedle patch stable at room temperature

Dissolving microneedle patches are a promising advance for influenza cutaneous vaccination due to improved immune responses using less immunogenic influenza antigens and enhanced stability.

Synthetic Charge-Invertible Polymer for Rapid and Complete Implantation of Layer-by-Layer Microneedle Drug Films for Enhanced Transdermal Vaccination.

A MN platform to shorten the application time in MN therapies based on a synthetic pH-induced charge-invertible polymer poly(2-(diisopropylamino) ethyl methacrylate- b-methacrylic acid) (PDM), requiring only 1 min skin insertion time to implant LbL films in vivo is developed.

A small-molecule dye for NIR-II imaging.

A rapidly excreted NIR-II fluorophore based on a synthetic 970-Da organic molecule (CH1055) that allowed targeted molecular imaging of tumours in vivo when conjugated with anti-EGFR Affibody and allowed precise image-guided tumour-removal surgery.

Thermostabilization of inactivated polio vaccine in PLGA-based microspheres for pulsatile release

Biocompatible Semiconductor Quantum Dots as Cancer Imaging Agents

Approximately 1.7 million new cases of cancer will be diagnosed this year in the United States leading to 600 000 deaths. Patient survival rates are highly correlated with the stage of cancer

High-fidelity replication of thermoplastic microneedles with open microfluidic channels

A novel manufacturing method that may overcome the complexity of hollow microneedle fabrication is reported that involves direct printing from computer-aided design (CAD) drawing without the constraints imposed by subtractive machining or etching processes.

The Nuts and Bolts of Low-level Laser (Light) Therapy

The mechanisms of action of LLLT at a cellular and at a tissular level are covered and the various light sources and principles of dosimetry that are employed in clinical practice are summarized.