Biocompatible Glycol Chitosan-Coated Gold Nanoparticles for Tumor-Targeting CT Imaging

@article{Sun2013BiocompatibleGC,
  title={Biocompatible Glycol Chitosan-Coated Gold Nanoparticles for Tumor-Targeting CT Imaging},
  author={I W Sun and Jin Hee Na and Seo Jeong and D R Kim and Ick Chan Kwon and Kuiwon Choi and Cheol-Hee Ahn and Kwangmeyung Kim},
  journal={Pharmaceutical Research},
  year={2013},
  volume={31},
  pages={1418-1425}
}
The application of gold nanoparticles (AuNPs) in biomedical field was limited due to the low stability in the biological condition. Herein, to enhance stability and tumor targeting ability of AuNPs, their surface was modified with biocompatible glycol chitosan (GC) and the in vivo biodistribution of GC coated AuNPs (GC-AuNPs) were studied through computed tomography (CT). Polymer-coated gold nanoparticles were produced using GC as a reducing agent and a stabilizer. Their feasibility in… CONTINUE READING
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