Biocompatibility of silicon-based arrays of electrodes coupled to organotypic hippocampal brain slice cultures.

@article{Kristensen2001BiocompatibilityOS,
  title={Biocompatibility of silicon-based arrays of electrodes coupled to organotypic hippocampal brain slice cultures.},
  author={Bjarne Winther Kristensen and Jens Noraberg and Pierre Thi{\'e}baud and Milena Koudelka-Hep and Jens Zimmer},
  journal={Brain research},
  year={2001},
  volume={896 1-2},
  pages={1-17}
}
In this study we examined the passive biocompatibility of a three-dimensional microelectrode array (MEA), designed to be coupled to organotypic brain slice cultures for multisite recording of electrophysiological signals. Hippocampal (and corticostriatal) brain slices from 1-week-old (and newborn) rats were grown for 4-8 weeks on the perforated silicon chips with silicon nitride surfaces and 40 microm sized holes and compared with corresponding tissue slices grown on conventional semiporous… CONTINUE READING