The purpose of the present review was to present a detailed description of those current scientific results and opinions relative to the biocompatibility of dental amalgam. The first section of the percent review to the pulpar reactions caused by amalgam fillings, especially when no protective base has been used, while the second part concerns itself with the biocompatibility of the dental amalgam per se. Specifically, reference is made to: a) the adverse reactions due to amalgam fillings both on the patient's physiological system and on the dentist's employing the material under consideration. b) those investigation results bearing a relation on the amount of mercury liberated during the amalgam filling procedures, i.e., mixing, condensation, finishing and polishing and/or removal of old amalgam fillings. c) Liberation of mercury, as well as metallic ions in the patients mouth cavity during chewing and/or during the process of intrabuccal galvanization and corrosion, and d) on the amount of mercury traced in the blood and urine of the patient following amalgam fillings. No conclusive evidence on any adverse reactions on the patient's health, attributable to the liberation of mercury from amalgam fillings, could be presented by the scientific investigations under consideration. Moreover, the number of cases reported on toxic reactions due to dental amalgam is negligible compared to the immense number of amalgam fillings performed in practice. It merits mentioning in this connection, however, the fact that the total amount of mercury attained by the patient from any other source, in conjunction with that liberated from amalgam fillings, could by all means contribute to a number of toxic reactions on the patient's health in general. Conclusively, one could state without reservations, that dental amalgam fillings per se are by and large free of toxic reactions on the patient, based on current scientific observations. Mentioning is finally made on several simple but nevertheless imperative precautions for the safety of public health.