Biocompatibility of a bicarbonate/lactate-buffered PD fluid tested with a double-chamber cell culture system.

@article{Fusshoeller2005BiocompatibilityOA,
  title={Biocompatibility of a bicarbonate/lactate-buffered PD fluid tested with a double-chamber cell culture system.},
  author={Andreas Fusshoeller and Jessica Baehr and Bernd Grabensee and Joerg Plum},
  journal={Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis},
  year={2005},
  volume={25 4},
  pages={387-93}
}
OBJECTIVE In peritoneal dialysis (PD), neutrally buffered PD fluids with lower concentrations of glucose degradation products (GDP) have tested superior to conventional fluids in terms of biocompatibility. However, conventional in vitro studies provoke debate because, due to the lack of subsequent equilibration with the blood, they do not resemble the true intraperitoneal situation of PD. METHODS We established a double-chamber cell culture system with peritoneal mesothelial cells seeded on… CONTINUE READING

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