Biochemistry of proinflammatory macrophage activation

  title={Biochemistry of proinflammatory macrophage activation},
  author={Y. Nonnenmacher and K. Hiller},
  journal={Cellular and Molecular Life Sciences},
  pages={2093 - 2109}
  • Y. Nonnenmacher, K. Hiller
  • Published 2018
  • Biology, Medicine
  • Cellular and Molecular Life Sciences
  • In the last decade, metabolism has been recognized as a major determinant of immunological processes. During an inflammatory response, macrophages undergo striking changes in their metabolism. This metabolic reprogramming is governed by a complex interplay between metabolic enzymes and metabolites of different pathways and represents the basis for proper macrophage function. It is now evident that these changes go far beyond the well-known Warburg effect and the perturbation of metabolic… CONTINUE READING
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