Biochemistry of neuromodulation in primary headaches: focus on anomalies of tyrosine metabolism

@article{Dandrea2007BiochemistryON,
  title={Biochemistry of neuromodulation in primary headaches: focus on anomalies of tyrosine metabolism},
  author={Giovanni D'andrea and Gianpietro Nordera and Francesco Perini and Gianni Allais and Franco Granella},
  journal={Neurological Sciences},
  year={2007},
  volume={28},
  pages={S94-S96}
}
Recent studies have suggested that abnormalities of dopamine and trace amines (tyramine, octopamine, and synephrine), products of tyrosine metabolism, may constitute the metabolic events that predispose to the occurrence of cluster headache (CH) and migraine attacks. This hypothesis is supported by the following evidences: the discovery of trace amine associated receptors (TAARs), expressed on the olfactory epithelium, amigdala, hypothalamus, periacqueductal gray, and the biochemical anomalies… 
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