Biochemistry of misonidazole reduction by NADPH-cytochrome c (P-450) reductase.


The biochemical mechanism for the reduction of misonidazole [1-(2-nitro-1-imidazolyl)-3-methoxy-2-propanol] by purified rabbit liver NADPH-cytochrome c (P-450) reductase, the primary nitroreductase of liver, has been studied. Neither the anaerobic nor the futile aerobic reduction velocities exhibited signs of Michaelis-Menten saturation at concentrations… (More)


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