Biochemistry of demyelination.

  title={Biochemistry of demyelination.},
  author={M. Louise Cuzner and William T. Norton},
  journal={Brain pathology},
  volume={6 3},
The myelin sheath, a lipid-rich multilamellar membrane of relative stability, both insulates and enhances conduction in nerve axons. A notable feature of myelin-specific proteins, in particular myelin basic protein, is their susceptibility to proteolytic activity and their encephalitogenicity, which induces inflammatory demyelination in the CNS. The final common pathway of myelin breakdown in vivo is well documented and there is evidence that myelin disruption can be mediated directly by… CONTINUE READING