Biochemistry of articular cartilage in health and disease.

  title={Biochemistry of articular cartilage in health and disease.},
  author={Klaus E. Kuettner},
  journal={Clinical biochemistry},
  volume={25 3},
Articular cartilage covers the ends of long bones in synovial joints, providing smooth articulation and cushioning of the underlying bone during joint movement. The tissue can be viewed as a viscoelastic, composite material composed of collagen type II (and smaller amounts of other collagens) entrapping compressed (underhydrated) proteoglycan aggregates which generate a high osmotic/swelling pressure. This abundant extracellular matrix (ECM) is synthesized and turned over by relatively few… CONTINUE READING