Biochemistry of V(D)J recombination.

  title={Biochemistry of V(D)J recombination.},
  author={David G Schatz and Eugenia Spanopoulou},
  journal={Current topics in microbiology and immunology},
The genes that encode immunoglobulin and T cell receptor proteins are assembled from component gene segments in a reaction known as V(D)J recombination. The reaction, and its crucial mediators RAG1 and RAG2, are essential for lymphocyte development and hence for adaptive immunity. Here we consider the biochemistry of this reaction, focusing on the DNA transactions and the proteins involved. We discuss how the RAG proteins interact with DNA and how coordinate cleavage of the DNA at two sites… CONTINUE READING

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