Biochemistry of Parkinson's disease with special reference to the dopaminergic systems

@article{Hirsch1994BiochemistryOP,
  title={Biochemistry of Parkinson's disease with special reference to the dopaminergic systems},
  author={Etienne C. Hirsch},
  journal={Molecular Neurobiology},
  year={1994},
  volume={9},
  pages={135-142}
}
The cardinal neurochemical abnormality in Parkinson's disease is the decreased dopamine content in the striatum, resulting from the loss of dopaminergic neurons in the mesencephalon. Precise analysis of the dopaminergic neurons in the midbrain demonstrates, however, that this cell loss is not uniform. Some dopaminergic cell groups are more vulnerable than others. The degree of cell loss is severe in the substantia nigra pars compacta, intermediate in the ventral tegmental area and cell group A8… CONTINUE READING
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