Biochemistry and toxicology of the diterpenoid glycoside atractyloside.

  title={Biochemistry and toxicology of the diterpenoid glycoside atractyloside.},
  author={David K. Obatomi and Peter H. Bach},
  journal={Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association},
  volume={36 4},
Atractyloside (Atr) is a diterpenoid glycoside that occurs naturally in plants (many of which are used in ethnomedicines) found in Europe, Africa, South America, Asia and the far East. It is also present in animal grazing forage. Atr (and its analogues) may be present at levels as high as 600 mg/kg dried plant material. Consumption of the plants containing Atr or carboxyatractyloside (carboxyAtr) has caused fatal renal proximal tubule necrosis and/or centrilobular hepatic necrosis in man and… CONTINUE READING
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