Biochemistry and regulation of pre-mRNA splicing.

  title={Biochemistry and regulation of pre-mRNA splicing.},
  author={Melissa D. Adams and David Z Rudner and Donald C. Rio},
  journal={Current opinion in cell biology},
  volume={8 3},
During the past year, significant advances have been made in the field of pre-mRNA splicing. It is now clear that members of the serine-arginine-rich protein family are key players in exon definition and function at multiple steps in the spliceosome cycle. Novel findings have been made concerning the role of exon sequences, which function as both constitutive and regulated enhancers of splicing, in trans-splicing and as targets for tissue-specific control of splicing patterns. By combining… CONTINUE READING