Biochemistry and physiology of mammalian secreted phospholipases A2.

  title={Biochemistry and physiology of mammalian secreted phospholipases A2.},
  author={G{\'e}rard Lambeau and Michael H Gelb},
  journal={Annual review of biochemistry},
Phospholipases A(2) (PLA2s) are esterases that hydrolyze the sn-2 ester of glycerophospholipids and constitute one of the largest families of lipid hydrolyzing enzymes. The mammalian genome contains 10 enzymatically active secreted PLA2s (sPLA2s) and two sPLA2-related proteins devoid of lipolytic enzymatic activity. In addition to the well-established functions of one of these enzymes in digestion of dietary phospholipids and another in host defense against bacterial infections, accumulating… CONTINUE READING
Highly Influential
This paper has highly influenced 16 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS


Publications citing this paper.
Showing 1-10 of 184 extracted citations

Secretory phospholipase A2 in the pathogenesis of acute dengue infection

Immunity, inflammation and disease • 2017
View 4 Excerpts
Highly Influenced


Publications referenced by this paper.
Showing 1-7 of 7 references

Prostaglandins & other lipid mediators: a new phase, a new team.

Prostaglandins & other lipid mediators • 2004
View 3 Excerpts
Highly Influenced

Prostaglandins Leukot

M Murakami, I Kudo
Essent . Fat . Acids • 2004

Prostaglandins Leukot. Essent

M Lappas, GE Rice
Fat. Acids • 2004

D ow nl oa de d fr om w w w .a nn ua lr ev ie w s. or g by A L I: A ca de m ic L ib ra ri es o f In di an a on

B Ivandic, LW Castellani, XP Wang, JH Qiao, M Mehrabian
Arterioscler. Thromb. Vasc. Biol • 1999

Biochemistry 30:7318–29

F Ghomashchi, B-Z Yu, O Berg, MK Jain, MH. Gelb
y. ANRV345-BI77-21 ARI • 1991
View 1 Excerpt

Similar Papers

Loading similar papers…