Biochemistry and physiology of mammalian secreted phospholipases A2.

@article{Lambeau2008BiochemistryAP,
  title={Biochemistry and physiology of mammalian secreted phospholipases A2.},
  author={G{\'e}rard Lambeau and Michael H Gelb},
  journal={Annual review of biochemistry},
  year={2008},
  volume={77},
  pages={495-520}
}
Phospholipases A(2) (PLA2s) are esterases that hydrolyze the sn-2 ester of glycerophospholipids and constitute one of the largest families of lipid hydrolyzing enzymes. The mammalian genome contains 10 enzymatically active secreted PLA2s (sPLA2s) and two sPLA2-related proteins devoid of lipolytic enzymatic activity. In addition to the well-established functions of one of these enzymes in digestion of dietary phospholipids and another in host defense against bacterial infections, accumulating… CONTINUE READING
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