Biochemistry and physiology of blood coagulation.

@article{Mann1999BiochemistryAP,
  title={Biochemistry and physiology of blood coagulation.},
  author={Kenneth G. Mann},
  journal={Thrombosis and haemostasis},
  year={1999},
  volume={82 2},
  pages={
          165-74
        }
}
  • K. Mann
  • Published 1 August 1999
  • Biology
  • Thrombosis and haemostasis
Introduction: The biochemical investigation of a biological process can be divided into three segments. The first is the development of an inventory of the components involved in the process, the second is the establishment of the connectivity between components, and the third is the establishment of the dynamics of the processes as they occur in the living organism. 

Figures and Tables from this paper

Biochemie und Physiologie der Blutgerinnung und Fibrinolyse

The principles of initiator and amplification reactions of blood coagulation and fibrinolysis will be presented and discussed in relation to various regulatory pathways of haemostasis. In particular,

Chapter 36 Disorders of the blood coagulation-fibrinolytic system

The role of the blood coagulation-librillolytic system in hemostasis, its pathological alterations and treatmellt of the disorders are surveyed.

Models for reaction mechanisms in haemostasis--contributions from the study of prothrombin activation.

A link between the "classical theory" of hemostasis and the conceptual development of activation complexes as the activators of the precursors of coagulation proteases is developed.

Thrombin as a Regulator of Inflammation and Reparative Processes in Tissues

Mechanisms of regulatory effects of thrombin on mast cells associated with nitric oxide release are discussed and functions involved in its interaction with PAR family receptors, activation of platelets, endothelial cells, leukocytes, smooth muscle cells, and mast cells are reviewed.

ES04.01 
Physiology of haemostasis

The way the system works in the light of the circumstances in which it can go wrong is considered, concentrating on an explanation of how various defects, demonstrable in the laboratory, have such strikingly different clinical consequences.

The Role of Coagulation in Arterial and Venous Thrombosis

The coagulation cascade is integral to the hemostatic process and serves to limit the amount of blood loss during trauma. However, derangements in this process can result in venous thrombosis and

Communication The kinetic model and simulation of blood coagulation—the kinetic influence of activated protein C

A computational modeling study with various assumption made of kinetic rates laws and their summation results in an interesting outcome, that kinetic reaction rates may show oscillation behavior under particular, high levels of protein C feedback inhibition.

A Comprehensive Model for the Humoral Coagulation Network in Humans

The model developed in this study is the first quantitative description of the comprehensive coagulation network and predicts the concentration–time and time–effect profiles of warfarin, heparins, and vitamin K in humans.
...

References

SHOWING 1-10 OF 55 REFERENCES

The roles of protein C and thrombomodulin in the regulation of blood coagulation.

  • C. Esmon
  • Biology, Medicine
    The Journal of biological chemistry
  • 1989
The data presented here suggest that deficiencics in protein S, thrombomodulin, or the platelet receptor for activated protein C might also result in a thromBotic tendency.

AN ENZYME CASCADE IN THE BLOOD CLOTTING MECHANISM, AND ITS FUNCTION AS A BIOCHEMICAL AMPLIFIER

It has been shown that contact activates Factor XII (Hageman factor) perhaps by unfolding its molecule, which leads successively to the activation of Factors XI (PTA) and IX (Christmas factor), and X (Stuart–Prower factor), the evidence suggesting that all these reactions are enzymatic.

An Enzyme Cascade in the Blood Clotting Mechanism, and its Function as a Biochemical Amplifier

It has been shown that contact activates Factor XII (Hageman factor) perhaps by unfolding its molecule, which leads successively to the activation of Factors XI (PTA) and IX (Christmas factor), and X (Stuart–Prower factor), the evidence suggesting that all these reactions are enzymatic.

Surface-dependent reactions of the vitamin K-dependent enzyme complexes.

It is concluded that factor VII is most likely a zymogen, just as are the other proenzymes of the blood clotting process, and the kinetic constants obtained for the various coagulation reactions determined in vitro provide some insights into how these pathways may function in vivo.

Waterfall Sequence for Intrinsic Blood Clotting

A simple waterfall sequence is proposed to explain the function of the various protein clotting factors during the formation of the fibrin clot. When clotting is initiated, each cloting factor except

Clotting Defect in Hemophilia

  • K. Brinkhous
  • Medicine, Biology
    Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine
  • 1947
The findings indicate that in hemophilia there is a deficiency in a plasma factor required for platelet utilization, and it is suggested that this factor is a thrombocytolysin.

Plasma Throinboplastin Component (PTC) Deficiency

A severe hemorrhagic disease, characterized by a prolonged whole blood coagulated time due to the delayed formation of thrombin, has been described and the name plasma thromboplastin component (PTC) has been assigned to this previously undescribed coagulation factor.

Identification of an endothelial cell cofactor for thrombin-catalyzed activation of protein C.

  • C. EsmonW. Owen
  • Biology, Chemistry
    Proceedings of the National Academy of Sciences of the United States of America
  • 1981
It is proposed that the surface of vascular endothelium provides a cofactor that enhances the rate of protein C activation by thrombin, and the activation rate is inhibited by including diisopropylphospho-thrombin in the medium.
...