Biochemistry and pharmacology of lipid antioxidants in acute brain and spinal cord injury.

@article{Hall1992BiochemistryAP,
  title={Biochemistry and pharmacology of lipid antioxidants in acute brain and spinal cord injury.},
  author={Edward D. Hall and P A Yonkers and Paula K Andrus and Joanna Cox and Douglas K. Anderson},
  journal={Journal of neurotrauma},
  year={1992},
  volume={9 Suppl 2},
  pages={S425-42}
}
Oxygen radical-mediated lipid peroxidation (LP) has been suggested increasingly to be an important factor in posttraumatic neuronal degeneration. Thus, numerous studies have evaluated the neuroprotective efficacy of pharmacological agents with lipid antioxidant activity in models of spinal cord and brain injury. Intensive pretreatment of animals with the endogenous lipid peroxyl radical scavenger vitamin E (i.e., alpha-tocopherol) has been shown to decrease posttraumatic spinal cord ischemia… CONTINUE READING
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