Biochemistry and cell signaling taught by bacterial effectors.

  title={Biochemistry and cell signaling taught by bacterial effectors.},
  author={Jixin Cui and Feng Shao},
  journal={Trends in biochemical sciences},
  volume={36 10},
Bacterial virulence often relies on secreted effectors that modulate eukaryotic signal transduction. Recent studies provide a collection of examples in which bacterial effectors carry out unprecedented posttranslational modifications of key signaling molecules or organize a new signaling network. OspF and YopJ families of effectors use novel modification activities to block kinase phosphoactivation. Targeting of the ubiquitin system by IpaH and Cif/CHBP families provides insights into host… CONTINUE READING
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