Biochemistry and cell biology of tau protein in neurofibrillary degeneration.

@article{Mandelkow2012BiochemistryAC,
  title={Biochemistry and cell biology of tau protein in neurofibrillary degeneration.},
  author={Eva-Maria Mandelkow and Eckhard Mandelkow},
  journal={Cold Spring Harbor perspectives in medicine},
  year={2012},
  volume={2 7},
  pages={a006247}
}
Tau represents the subunit protein of one of the major hallmarks of Alzheimer disease (AD), the neurofibrillary tangles, and is therefore of major interest as an indicator of disease mechanisms. Many of the unusual properties of Tau can be explained by its nature as a natively unfolded protein. Examples are the large number of structural conformations and biochemical modifications (phosphorylation, proteolysis, glycosylation, and others), the multitude of interaction partners (mainly… CONTINUE READING